Tagged with 'estrogen'

October is National Breast Cancer Awareness Month. More than 25 years ago, National Breast Cancer Awareness Month began to promote awareness of breast cancer issues. A collaboration of national public service organizations, professional medical associations, and government agencies joined together to form National Breast Cancer Awareness Month, or NBCAM, to promote awareness and share information. 

Breast cancer is the second most common type of cancer found in American women.

Second only to skin cancer, the rate of women developing breast cancer each year has stayed the same for the last decade. According to the National Cancer Institute, avoiding certain risk factors and increasing protective factors may help prevent cancer. Scientists continue to look at factors that can increase or decrease the risk of developing cancer, and at this point they have determined the following risks and possible protective factors. 

Factors that many increase the risk of breast cancer:

Estrogen

Hormones play a major role in different processes in our body. Estrogen is a hormone that helps the body to develop, and that is responsible for female sex characteristics. Estrogen levels are highest in women during their childbearing (menstruating) years, with levels decreasing with menopause. Women who began menstruating early, or do not begin menopause until later in life, increase the number of years that breast tissue is exposed to estrogen. Women who become pregnant later in life or never become pregnant also should be aware of the risks of prolonged estrogen exposure.

Hormone Therapy

Women who have been given hormone therapy, or hormone replacement therapy, to replace estrogen, progestin, or both (such as postmenopausal women or those whose ovaries have been removed), are at a higher risk of developing breast cancer. Studies have shown that halting these hormonal therapies decreases cancer risk. 

Radiation Exposure

Radiation therapy has been used to treat Hodgkin's disease, but studies have shown that this therapy can increase a women's risk of breast cancer. Exposure to radiation, such as a chest x-ray, can increase cancer risks, particularly if the radiation therapy or exposure occurred during puberty, or before 20 years of age.

Obesity 

If you are a postmenopausal women who is obese, your risks for breast cancer are elevated, even if you have not undergone hormone replacement therapy. This is one more in a long list of health reasons to maintain a healthy body weight at every age and stage of life. 

Alchohol

According to the National Cancer Institute, a women's risk of developing breast cancer rises as the amount of alcohol consumed rises. 

Genetic Inherited Risks

Changes in certain genes, such as BRCA1 and BRCA2, passed on to women increase their risk of breast cancer. These women may develop breast cancer at an earlier age than women without changes to these genes. If you have a family history of breast cancer, be sure to talk to your doctor about this risk.

Protective Factors that may decrease the risk of breast cancer:

Exercise

Premenopausal women of normal weight who exercise four or more hours a week have shown the greatest decrease in breast cancer risk. Exercise may decrease hormone levels, making this an important factor in overall and breast health.

Breast Feeding

Estrogen levels become lower during pregnancy, and women who breast feed maintain these lower estrogen levels longer than women who do not. Women who have had their first full-term pregnancy before the age of 20 also appear to have a lower risk of breast cancer later in life. Decreasing the length of time that breast tissue is exposed to estrogen seems to be a factor in helping to prevent breast cancer.

Aromatase Inhibitors

Aromatase inhibitors block the action of an ezyme called aromatase, which is used to make estrogen in the body. Women with an increased risk of breast cancer, such as postmenopausal women with a personal history of breast cancer, may decrease that risk by taking aromatase inhibitors, which decrease the amount of estrogen made in the body.

Prophylactic Mastectomy or Oophorectomy

Some women with very high risks of developiing breast cancer may elect to have a prophylactic mastectomy (the removal of both breasts when there are no signs of cancer), or a prophylactic oophorectomy (the removal of both ovaries when there are no signs of cancer). Although both of these procedures can lower cancer risks, it is very important to discuss these in depthly with both medical professionals and counselors, and  have professional cancer risk assessments done. These procedures can be life altering, and many other long-term effects can accompany them. These are extreme measures of risk management not to be taken lightly.

This year, actress Angelina Jolie brought global media attention to prophylactic mastectomies when she elected to have her breasts removed to decrease her risk of developing breast cancer. 

Fenretinide

Fenretinide is a type of retinoid, or vitamin A. Postmenopausal women with a family history of breast cancer that have been given fenretinide have shown decreased risks of breast cancer. Fenretinide may be effective by causing a wax-like substance known as ceramide to build up in tumor cells and kill them. This retinoid does have some potential harmful side effects; long term use may lead to night blindness and skin disorders. Pregnant women must avoid fenretinide because it can harm a developing fetus. 

Clinical trials continue to take place across the country as researchers attempt to further define the factors that can increase or decrease a women's risk of breast cancer.

Exciting results in natural therapies continue to arise...

One such trial on the anti-tumor effects of reishi mushroom provided evidence that reishi supresses protein synthesis and tumor growth in in vivo and in vitro models, suggesting that this medicinal mushroom has potential natural therapeutic properties for breast and other cancers.

Another trial studied the effect of curcumin (turmeric) and silibinin's (milk thistle extract) effects on telomerase gene expression in cancer cells. Telomeres are required to protect chromosomal ends, preventing DNA from fraying away. Normal cells have active telomerase, but telomerase is implicated in tumor progession and is commonly expressed in human cancer cells. A telomerase gene in humans is known as hTERT. The conclusion of this study was that cell viability along with hTERT gene expression in breast cancer cells could be reduced by these two herbal substances, making turmeric and milk thistle two herbal substances that may have potential and exciting futures as anti-cancer agents. 

October may be designated as Breast Cancer Awareness Month, but breast cancer affects both women and men all year long. There have been an estimated 232,340 new cases of breast cancer in women thus far in 2013 alone. It is important to know your risks, your family history, and to speak to a medical professional about risk factors, screening, and testing. 

Melissa Zimmerman, Healthy Goods

References:

National Beast Cancer Awareness Month; About NBCAM.org; www.nbcam.org; 

National Cancer Institute at the National Institute for Health; What is Prevention?http://www.cancer.gov/cancertopics/pdq/prevention/breast/Patient/page1

PubMed; Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models; http://www.ncbi.nlm.nih.gov/pubmed/23468988

PubMed; Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells; http://www.ncbi.nlm.nih.gov/pubmed/23886126

Myomin and estrogen balance.